Z700665
Sigma
Combinatorial Library: Methods and Protocols
| ISBN-10: | 0-86903-980-3 |
| ISBN-13: | 978-0-86903-980-9 |
Description
| General description | A panel of expert researchers have collected a novel series of computational and laboratory methods for the design, synthesis, quality control, screening, and purification of such combinatorial libraries. Here the reader will find cutting-edge techniques for the preparation of encoded combinatorial libraries, for the synthesis of DNA-binding polyamides, and for combinatorial receptors. There are also state-of-the-art methods for computational library design, quality control by mass spectrometry, and structure verification using 1D and 2D NMR. |
Properties
| publication info | L. English, ed., Humana Press, 2002, 396 pp., hard cover |
Table Of Contents
| Table of Contents | PART I. Library Synthesis and Quality Control Using a Noncovalent Protection Strategy to Enhance Solid-Phase Synthesis Quality Control of Solid-Phase Synthesis by Mass Spectrometry Preparation of Encoded Combinatorial Libraries for Drug Discovery Simple Tools for Manual Parallel Solid Phase Synthesis Cleavage of Compounds from Solid Phase by Gaseous Reagents Synthesis of DNA-Binding Polyamides: Robust Solid-Phase Methods for Coupling Heterocyclic Aromatic Amino Acids The Preparation of Phenyl-stilbene Derivatives Using the Safety Catch Linker Host-Guest Chemistry: Combinatorial Receptors Automated Structure Verification of Small Molecules Libraries Using 1D and 2D NMR Techniques Rapid Liquid-Phase Combinatorial Synthesis of Heterocyclic Libraries Soluble Polymer-Supported Methods for Combinatorial and Organic Synthesis Analytical Methods for Optimization and Quality Control of Combinatorial Synthesis PART II. Library Purification and Screening Resolving Racemic Mixtures Using Parallel Combinatorial Libraries Ligand Libraries for the Extraction of Metal Ions: Dynamic Combinatorial and High-Throughput Screening Methods Automated Liquid-Liquid Extraction and Ion-Exchange Solid-Phase Extraction for Initial Purification On-Bead and Solution Screening Approaches for Genomically Derived Targets: Discovery of Surrogate Ligands and Substrates Using Combinatorial Chemistry Libraries PART III. Computational Library Design Design of Virtual Combinatorial Libraries Approaches to Library Design for Combinatorial Chemistry Reagent-Based and Product-Based Computational Strategies in Library Design Designing Combinatorial Libraries for Efficient Screening Application of Neural Networks to Large Dataset QSAR, Virtual Screening, and Library Design Index |
